QuoVadis: Evaluating variation among anthelmintic drug responses to support the control and elimination of human helminthiases

This project involves evaluating variation in individuals’ responses to the drugs distributed to millions of people around the world as part of the World Health Organization’s strategy of preventative chemotherapy to control and eliminate human helminthiases. This work will define expected levels of inter-person variation in drug responses for use as a reference to identify suspicious or suboptimal responses—potentially indicative of emerging drug resistance—in people exposed to multiple rounds of mass drug administration.