Praziquantel in Preschool Children (PIP trial)

The Praziquantel in Preschoolers trial (PIP) aims to find the right treatment dose of praziquantel for preschool children living with intestinal schistosomiasis in Uganda.

Intestinal schistosomiasis is a complex parasitic disease that affects millions of children worldwide. With only one drug to treat it (praziquantel), there is still no optimal dosing for children under 5 years of age.

The PIP trial (Praziquantel in Preschoolers) is a five year randomised controlled trial investigating different doses and treatment intervals of praziquantel given to children under five years of age. It will also explore the role of intestinal pathology on the pharmacokinetics and pharmacodynamics of praziquantel and its role in drug efficacy.